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Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice

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We assessed the diverse functional association of protein domains by analysing core functional clans, and determined similar patterns of dominance for carbohydrate, amino acid and lipid processing-associated domains (Extended Fig

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Fluorescent images were captured using a Leica DM4B microscope, and at least three images from different animals in each group were quantitatively analyzed