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Diets high in UPFs may trigger both peripheral and central inflammatory responses, resulting in elevated triglyceride and TNF- levels in the liver, as well as increased IL-6 concentrations in the prefrontal cortex, as observed in animal models (116, 117) (Figure 10)

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Focal ischaemia can trigger local damage to the nervous tissue ranging from cell death at the ischaemic core and various degrees of functional cellular deficits in the ischaemic penumbra

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It is not a cost-effective first-line test in a post-weight-loss screening context