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doi: 10.2174/1573399815666190115145702 6 American Diabetes Association Professional Practice Committee

These GLP-1 analogs affect glucose-dependent insulinotropic polypeptide receptors and glucagon receptors, in addition to GLP-1R and are expected to exhibit stronger anti-obesity effects than that of semaglutide [21, 22]

The purpose of this review is to (1) detail the renal and cardiovascular mechanisms of incretin-based therapies, (2) summarize the clinical evidence from completed and ongoing CVOTs, (3) discuss emerging agents such as the dual GLP-1/GIP agonist tirzepatide, and (4) highlight remaining knowledge gaps as the therapeutic paradigm shifts from glucose-centric to cardiorenal-centric care

For readers comparing GLP-1 options, our tirzepatide guide may also help you compare treatment paths