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Whole blood and plasma samples of six JVC rats were collected at 0.05, 0.167, 0.5, 1, 2, 4, 8, 24, 48, and 72 h after administration (three males and three females at each time point) for the examination of radio pharmacokinetics of total plasma

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CJC-1295 without DAC (Modified GRF 1-29) has a plasma half-life of approximately 30 minutesfar shorter than the DAC version's 68 days

The rationale is that pulsatile GH release may have different tissue effects than continuous elevation, though this has not been proven in comparative studies

Chemokines, particularly those secreted by melanocytes, are essential to the pathophysiology of vitiligo