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Smith et al., 2003)

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Studies have shown that trypsin induces the release of calcium ions from vascular endothelial cells, causing coronary artery-dependent vasodilation and reducing the contractile sensitivity of smooth muscle [79]

The impact of energy deprivation on the signaling pathways of erythrocytes was later disclosed in a mechanistic study: here, the authors demonstrated that removal of extracellular glucose and blockade of glycolysis by 2-deoxyglucose leads to fast depletion of cellular ATP

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