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10.1093/jjco/hyf035 [DOI] [PubMed] [Google Scholar] Baric M., Sever A

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MOTS-c is encoded in mitochondrial DNA and influences aging, cardiovascular health, metabolic balance (insulin sensitivity and weight control), and inflammation via pathways like AMPK and NRF2. It acts as a hormone-like messenger from mitochondria to the rest of the system, supporting metabolic homeostasis