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a , b , Comparison of wild-type GLP-1R and the R176 2.46b Q mutant by GLP-1 binding assay ( a ) and functional cAMP accumulation assay ( b )

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Essential apoptotic proteins such as Bcl-2, Bax, Sirt1, and caspase-3 were altered after luteolin treatment, which was confirmed through various studies, including cell cycle analysis, cell viability assays, and annexin-V/propidium iodide staining [235]