Although many of the studies of DA metabolites were performed on patients with different types of parkinsonism, with different degrees of severity, and the fact that many of these studies were made using small sample sizes, there is a general consensus that CSF HVA levels are decreased in untreated PD patients and rise after levodopa therapy starts (decreased HVA may not be present in early stages of PD)
Waget A, Cabou C, Masseboeuf M, Cattan P, Armanet M, Karaca M, Castel J, Garret C, Payros G, Maida A, Sulpice T, Holst JJ, Drucker DJ, Magnan C, and Burcelin R
Staying hydrated supports detoxification
Lancet , 404(10469), 2278-2298
Efficiency and absorption matter far more than sheer volume
L carnitine, diyet dnemlerinde olan kiilerin ya yakm srecinin hzlanmasna yardmc olmaktadr