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The Phase 2 trial , published in the New England Journal of Medicine, tested doses from 1 mg to 12 mg over 48 weeks
Where To Put The GLP-1 Patches
10.1056/NEJMoa2306963 [DOI] [PubMed] [Google Scholar] 79
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BMI thresholds still exist because clinical trials primarily studied patients meeting specific BMI requirements, and FDA indications and insurance policies are generally based on those populations
A subsequent 2025 in vitro study reported that Akkermansia muciniphila extracts produced a dose-dependent increase in GLP-1 secretion from human L-cell lines
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