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At locations where renal interstitial fibrosis occurs, there is an upregulation of PDGF-C expression, which stimulates PDGFR to further the fibrotic process (Eitner et al., 2008
On the basis of the biological plausibility and anecdotal case reports of clinical improvement, (in)GSH has been recommended as an off-label therapy for GSH augmentation in PD since 2004
The databases used were PubMed, maintained by the US National Library of Medicine at the National Institutes of Health, Science Direct and Scopus by Elsevier, and Google Scholar (retrieved from 1 June to 26 August 2025)
Depleting cellular antioxidants makes ROS more effective at killing cancer cells because this is the traditional treatment strategy for doing so
"Aging- and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo"
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