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& Keane, J
At present, Novo Nordisk has developed injection preparations (Ozempic) and oral preparations (Rybelsus) for semaglutide: Ozempic (semaglutide, injection preparation): is a weekly subcutaneous injection preparation (0.5mg or 1mg), suitable for: (1) as an auxiliary means of diet adjustment and exercise to improve blood sugar control in adult patients with type 2 diabetes (2) It is used for adult patients with type 2 diabetes with cardiovascular disease (CVD) to reduce the risk of major adverse cardiovascular events (MACE, including cardiovascular death, non-fatal heart attack, and non-fatal stroke)
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J Lipid Atheroscler 2023
The short half-life of endogenous GLP-1 has led to the development of GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors as therapeutic strategies to extend the duration of GLP-1 action in the treatment of type 2 diabetes (17)
Evans blue extravasation refers to the potential leakage of Evans blue dye from blood vessels into the surrounding tissues, which potentially indicates increased vascular permeability, possibly associated with inflammation
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