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Thus, substantial and mounting evidence supports a direct contributory role of gut microbiota as a participant in CVD pathogenesis, and preclinical studies indicate that the therapeutic targeting of microbial contributors to the TMAO metaorganismal pathway may hold promise as a novel approach for the prevention or treatment of CVD

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doi: 10.1056/NEJMoa2206038 [DOI] [PubMed] [Google Scholar] 7.Kumar S, Blaha MJ