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& Quitmann, J

To minimise these effects, take metformin with or immediately after meals, and consider extended-release formulations if standard metformin causes significant digestive upset

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The exceptional in vitro potency is attributed to its mechanism of acting as an allosteric potentiator of HGF binding to c-Met (amplifying an endogenous signal), which produces non-linear dose-response curves

400 mg/day, respectively

However, using peptides can become expensive