A trial of reperfusion therapy for ischemic stroke indicated that semaglutide, which has a strong GLP-1R-mediated neuroprotective effect, could reduce the infarct size in acute ischemic stroke in non-diabetic rats (89)
GLP-1 helps regulate blood sugar levels, slow gastric emptying, and signal satiety to the brain
These are signs that the glucagon component is driving energy expenditure at a level that meaningfully contributes to the overall weight loss beyond what GLP-1 and GIP provide alone
They make the category investable By standardizing CAC, retention, staffing, and fulfillment, they make it easier for growth funds to invest downstream
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For subcutaneous semaglutide, this is the 2.4 mg weekly dose