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Side effects to Vitamin B12 are SO rare that they cannot be estimated from current data (in other words, less than 1 in 10'000)

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Sleep Breath 27:16871694 [DOI] [PMC free article] [PubMed] [Google Scholar] 8.De Iannella G, Marchese Pace A, Bellizzi MG, Magliulo G, Greco A, Virgilio A, Croce E, Gioacchini FM, Re M, Costantino A, Casale M, Moffa A, Lechien JR, Cocuzza S, Vicini C, Caranti A, Aragona R, Lentini M, Maniaci A (2025) The Global Burden of Obstructive Sleep Apnea

For example, rhodopsin has been shown to inhibit LPS-induced expression of pro-inflammatory cytokines in macrophages, reducing inflammatory cell infiltration and ameliorating liver function

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