In addition, GLP-1, but not GIP, inhibits glucagon secretion, and together these actions form the basis for the use of GLP-1 receptor agonists (GLP-1RAs) in T2DM therapy [6]
doi: 10.1074/jbc.R111.287995
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The jump from 1mg to 4mg produced nearly double the weight loss, from 8.7% to 17.1%, suggesting that the glucagon component only becomes meaningfully active somewhere in that dose range
