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The neuroendocrine phenotypes, melanin formation, and elevated level of vanillylmandelic acidic in urine in some cases suggest a neurocrest origin of these tumors 8, 11

Analysis of tumour samples showed an upregulation of p21 CIP1 and p27 on palbociclib treatment and a significant reduction when compared with the palbociclib + RSL3-treated mice (Fig