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P450 reductase catalysis produces superoxide radicals, which can, in the presence of superoxide dismutase and Fe 3+ , form highly reactive hydroxyl radicals capable of damaging virtually all macromolecules

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References Ristoff E, Augustson C, Geissler J, de Rijk T, Carlsson K, Luo JL, Andersson K, Weening RS, van Zwieten R, Larsson A, Roos D: A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia

Aerosol orgotein (Ontosein) for the prevention of radiotherapy-induced adverse effects in head and neck cancer patients : a feasibility study

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