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2022 Feb;44(2):215-227

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High baseline oxidative stress or chronic inflammation may theoretically justify antioxidant support, but this remains individualized and requires provider interpretation

The investigators conducted a multicenter, double-blind, placebo-controlled, active-controlled phase 3a trial (ClinicalTrials.gov ID: NCT05567796) evaluating the efficacy and safety of the combination of semaglutide and cagrilintide in adults without diabetes with a body-mass index (BMI) of greater than or equal to 30 or greater than or equal to 27 with at least one obesity-related complication

These findings remain research-context findings