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First, an overall reduction in glycolysis and/or PPP activity with MEK inhibition and SHP2/MEK combination therapy was observed, and virtually all the cell lines analyzed demonstrated sensitivity to glycolysis inhibition and corresponding transcriptomic alterations, highlighting the conserved dependency of PDAC on glycolytic pathways, which is consistent with the finding that KRAS signaling supports anabolic glucose metabolism

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doi: 10.1111/j.1600-0714.1990.tb00825.x

The transparency of the crystalline lens decreases with age, leading to a gradual increase in absorbance within the blue light spectrum (Lee et al., 2016)

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