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However, despite these promising findings, the potential role of GLP-1RAs in PsA, particularly as a dual-action agent targeting both metabolic and immune dysregulation, remains insufficiently explored

2 Immune cell mitochondrial dysfunction mechanisms in the perioperative period The perioperative period represents a convergence of multiple physiological stressorsincluding tissue ischemiareperfusion, mechanical injury, anesthesia exposure, and neuroendocrine surgesthat collectively challenge immune cell homeostasis at the mitochondrial level