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In addition to the previously mentioned target pathways, we have also identified that drugs can alleviate LPS-induced lung injury in mice through mechanisms such as the STAT3 signaling pathway and miR-21/PTEN axis (Figure 3) [111, 117-121]

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Their cohort included 100 adults (53.1% women) aged 18 to 75 years (mean age = 41.1 years) with a history of seasonal allergic rhinitis of 2 or more years and a positive skin prick test or specific IgE at baseline or within the 12 months before enrollment