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For example, the standard semaglutide (Wegovy) protocol exponentially escalates the dose every 4 weeks 0.25 mg for 4 weeks, then 0.5 mg, 1.0 mg, 1.7 mg, and finally 2.4 mg/week by about week 16 (source)

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Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors