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However, due to rare but serious adverse effects (e.g., thrombocytopenia, cardiac arrhythmias, hypersensitivity reactions), many guidelines recommend against routine use

A clinical comparison found retinaldehyde comparable in efficacy to retinoic acid for photoaging while being better tolerated

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Selank is a synthetic analog of tuftsin with anxiolytic and nootropic properties, studied more for anxiety reduction, mood stabilization, and cognitive protection under stress

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