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Similar results were derived from the analysis of Italian administrative health databases of the Lombardy region, demonstrating a greater risk of hospitalization for renal disease compared to SGLT-2i (HR 2.23, CI 95% 1.483.43) [38]

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The Precision Peptide Genetic Test identifies these predispositions in key peptide pathway genes, allowing providers to contextualize dosing strategies before escalation

1 A randomised double-blind trial of 130 women showed that adding NAC to letrozole produced more mature follicles and a modest but statistically significant pregnancy rate improvement (p = 0.045) compared with letrozole plus placebo