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An analysis published in JAMA Internal Medicine in 2022 found that patients using GLP-1 receptor agonists had a higher incidence of gallbladder-related events compared to those using other diabetes medications

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[DOI] [PubMed] [Google Scholar] 54.Sakr SA, Badawy GM

This sustained action leads to a far stronger effect on appetite suppression and blood sugar control than what the body can achieve naturally, which is why these medications are highly effective treatments for type 2 diabetes and obesity