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Furthermore, when using cholesterol hydroperoxide (ChOOH, a specific GPX4 substrate) as a stressor, compound 102 could activate GPX4 in intact cells and protect them from ChOOH toxic effects ( Supplementary Figure S12B )
(PubMed) Sethumadhavan S, Chinnakannu P
Although more drugs are consumed by women as compared to men, and, although for some of the (dose-dependent) cases of DILI differences in the volume of distribution or drug-metabolizing enzyme expression have been suggested to account for the gender differences, there remains a significant part of all DILI cases where the sex-dependent increase in risk cannot be explained by increased exposure.90 Some authors has found no sex differences related to antithyroids-induced hepatotoxicity.82 Hyperthyroidism is more common in women91 and it has been found that the incidence of grave's disease is more frequent in females.92 Hence, any probable relationship between patients, sex and antithyroid drugs-induced hepatotoxicity might be simply due to the more rate of antithyroid drug prescription in females
H NMR-based metabolomics profile of green and red Amaranthus grown in open field versus greenhouse cultivation system
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