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Nevertheless, deficiency or oxidation of L-arginine and tetrahydrobiopterin (BH 4 ), which are two essential cofactors for eNOS action, are associated with the uncoupling of the L-arginine-NO pathway that results in the decreased formation of NO and increased eNOS-mediated generation of superoxide

Addition of pyridostigmine allows the protective ratio to exceed 5 for soman (according to animal studies in monkeys & guinea pigs)(FDA 2026)

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Even 60 seconds of hold time instead of 120 reduces absorption significantly

But trials would have to be enormous to exclude an increased risk, and unless the rules change radically by the time they are to be reported, most of the data will remain hidden from independent scrutiny

Expectant mothers: respect the expiry date