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10.1016/bs.apha.2016.08.001 133 MendlerA

doi: 10.1016/j.neuropharm.2022.108963 163 DenkDSinghAKaslerHAlcober BoquetLDAmicoDGorolJet al

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The expression levels of seleno-GPxs can be increased either through transcriptional induction or by elevating bioavailable selenium which supports their translation [8, 20, 24,25,26,27]

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3.3.1 Anti-inflammatory agents Given that oxidative stress is a powerful trigger for inflammation, forming a vicious cycle of tissue damage, targeting the inflammatory cascade is a rational, albeit indirect, strategy to mitigate the downstream consequences of the initial oxidative insult