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Estrogen was also shown to play a crucial role in controlling oxidative stress, a major contributor to impaired wound healing, by increasing the production of antioxidants, such as superoxide dismutase (SOD), and promoting B-cell lymphoma 2 (BCL2) expression, via activation of the nuclear factor erythroid 2-related factor (NRF2) (Kanda and Watanabe, 2003

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Author contributions ZJ, TI, and HN designed research, performed experiments, analyzed data, and wrote the manuscript

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Recent evidence has shown that oxidative stress plays a crucial role in the pathogenesis of neuralgias

WPC concentrations, ethanol concentrations and genipin concentration) was observed on hydrodynamic size (HD), zeta potential (ZP) and entrapment efficiency (EE)