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NICE guidance (NG28) recommends GLP-1 receptor agonists like Trulicity as a treatment option for adults with type 2 diabetes when: Triple therapy is required (in combination with metformin and another oral drug) The patient has a BMI 35 kg/m (or lower thresholds for some ethnic groups) with specific psychological or medical problems associated with obesity Insulin therapy would have significant occupational implications or weight loss would benefit other obesity-related comorbidities Importantly, NICE recommends continuing GLP-1 receptor agonist treatment only if the patient has had a beneficial metabolic response (a reduction of at least 11 mmol/mol [1.0%] in HbA1c and weight loss of at least 3% of initial body weight) after 6 months

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