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These doses were used within a controlled research environment with rigorous safety monitoring they do not represent guidance for use outside of trials
A 2.5 mg track has short direct data and real-world support for stable maintainers, but continuing tirzepatide has much stronger evidence than stopping. At week 112, stepping down to 5 mg preserved 16.6% weight loss versus 21.9% on the top dose and 9.9% on placebo
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Traditional treatment for rib injuries remains remarkably limited
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