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Individuals with sluggish liver function or detox challenges , where hepatic support may aid metabolic clearance
Both peptides are supported almost entirely by preclinical (animal and in-vitro) data, with zero completed Phase III human trials
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However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind
Following methodical steps improves overall laboratory safety and preparation accuracy
