The exemplary mimic, Dihexa, binds to HGF with extraordinary affinity (Figure 43), blocking HGF dimerization (Figure 44), and markedly augments the ability of HGF to signal to c-Met (Figure 45) and initiate cellular responses (as discussed above)
Gastrointestinal (GI) side effects in patients, such as nausea, diarrhea, abdominal discomfort, or constipation, can occur with both drugs
Geistlinger L, Csaba G, Zimmer R
They are approved for type 2 diabetes, not Wegovy's 2.4 mg weight-management dose, but off-label prescribing for weight loss is common
Timper K, Grisouard J, Sauter NS et al (2013) Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes
Key Takeaway: The best medication is the one that is safely prescribed for your specific health profile and supported by a team of experts who understand the nuances of metabolic health