Metformin is a strongly basic hydrophilic drug with a pKa of approximately 11 is not metabolized and is excreted principally by the kidney
The result is softer, healthier-looking skin that feels comforted and revitalized
(2023) Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis Snyder, Peter J
Baseline fasting glucose, HbA1c, a lipid panel, and inflammatory markers establish the clinical context, and the post says repeating them periodically lets a provider judge metabolic trajectory beyond weight alone
Certainly, an increase in IGF-1 action is associated with greater risk for neoplastic disease, a link further supported by this study and others targeting IGF-1Rs, but IGF-1 has been paradoxically associated with protection against osteoporosis, type 2 diabetes, cerebrovascular and cognitive decline in pre-clinical studies, as well as in some human epidemiologic studies 12
As with any prescription medication, some patients may experience mild side effects like nausea, constipation, or fatigue
