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In sum, it is believed that, at least in part, PT-141 results in increased production of nitric oxide (NO) synthesized from neuronal nitric oxide synthase (nNOS), with the NO activating soluble guanylate cyclase to catalyze the conversion of guanosine triphosphate (GTP, also called guanosine 5'-triphosphate) to cGMP

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Injection site irritation Mild redness, swelling, or tenderness at the injection site

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Most gastrointestinal symptoms peak during dose escalation and may diminish over time as tolerance develops