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But the same trial flagged more atrial fibrillation, more blood clots, and, in a follow-up, more broken bones, most of them from ordinary falls, for reasons nobody has fully explained (New England Journal of Medicine, 2024)

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Polypharmacy involving the use of combination drug therapies is standard care in the treatment of bipolar disorder, but involves higher costs and burden, as well as increased risk of drug-to-drug interactions [9]