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When mast cells encounter a trigger, they release histamine, evoking the release of 3 neuropeptides from the neighboring sensory nerves, a process known as neurogenic inflammation

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Beyond the specific leads identified, this work underscores the power of consensus-based virtual screening to uncover non-intuitive solutions to complex molecular recognition challenges, effectively streamlining the development of next-generation GLP-1R modulators

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They are fundamental biological processes that operate across all vascularized tissue types