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In the STEP 1 Trial Extension [22], of the original 1961 participants, 327 were observed off drug for 52 additional weeks

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GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors