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Rather than manipulating individual pathways in isolation, effective intervention will likely require coordinated, context-dependent modulation of chaperones, autophagy, UPS activity, and ER stress responses

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In addition to improving glycemic control, GLP-1RAs promote satiety, reduce visceral adiposity, and exert indirect anti-inflammatory effects (35)

Erastin induces ferroptosis in tumor cells and enhances the therapeutic ability of conventional antitumor drugs such as doxorubicin and cisplatin [116, 117]