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Second, enrolled populations differed substantially with respect to baseline cerebrovascular risk and clinical context (recent ACS in ELIXA vs chronic stable atherosclerotic disease vs mixed primary prevention in REWIND), which can alter stroke subtype distribution and the time course over which vascular risk modification translates into event reduction [44,46]

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While this type of testing is not the same as FDA approval, it can provide an additional layer of quality assurance beyond internal processes

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