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For context, the best results with semaglutide top out around 15 to 17 percent, and tirzepatide reaches approximately 20 to 22 percent

Long-term deficiency could potentially lead to nerve damage

Taken together, preclinical and clinical studies have demonstrated that GLP-1 receptor agonists exert pleiotropic effects extending beyond glycemic control, influencing multiple organ systems including the nervous, respiratory, hepatic, renal, cardiovascular, reproductive, and immune systems (Figure 4)

An imbalanced gut microbiome common during perimenopause as oestrogen levels affect the estrobolome (the collection of gut bacteria that help metabolise oestrogen) can therefore directly affect your ability to produce the chemicals needed for restful sleep

[DOI] [PubMed] [Google Scholar] 71.Lew E

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