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Combination of PIO with SLGT2 inhibitors Preclinical evidence The possible activities of ipragliflozin (IPRA), PIO or their combination on a variety of diabetic features (IR, hyperinsulinemia, obesity, dyslipidemia) and the progression to NASH were explored after their administration to high-fat diet-fed KK/A y T2D mice [113]

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However, simply combining two commercially available drugs into one, without a prescribers adjustment of dosage form or strength, would be considered a copy under a strict reading of US Food and Drug Administration (FDA) guidance, Brunner says

Its an elegant, self-regulating system