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Phase 2 data in type 2 diabetes showed CagriSema reduced HbA1c by 2.2 percentage points compared to 1.8 with semaglutide alone and 0.9 with cagrilintide alone, while achieving 15.6% weight loss versus 5.1% with semaglutide alone

Garzotto et al., 2008)

In addition, AMP-activated protein kinase (AMPK) inhibits mTOR, thereby affecting the PI3K-AKT pathway, which is involved in the regulation of fibrosis (Hui-Yun et al., 2020)

(2) Methodological variations: The referenced studies employed the GSSG substrate method or a modification of Beutlers method, while our study utilized the ultraviolet enzymatic method

doi: 10.1210/jcem.86.2.7240 28 BirznieceVHoKKY

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