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If GSH is severely depleted by the toxic metabolite of acetaminophen, NAPQI (Figure 3b), and/or there is inadequate glycine to produce GSH due to illness or nutritional deficiency, there is a lack of negative feedback of GSH on -glutamylsynthetase
Included in those differences may be certain defects, variations, or mutations
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[2] [5] The administration of Glutathione Injection may be associated with both common and rare side effects
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