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Limitations This observational cohort study must be interpreted with caution and can establish associations but not causality

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Gut peptide hormones such as GLP-1 could potentially also have an impact on appetite regulation by effects on gastric emptying and direct CNS effects, but we needed a robust methodology that could be used to measure acute effect of putative hormones on subjective appetite and spontaneous food intake

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Additionally, through microbial modulation, FMT appears to improve intestinal barrier functioning and reducing intestinal permeability, providing an important contribution in NAFLD/NASH management by decreasing hepatic fat accumulation and inflammation, both in humans and mice [80]