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This is not a formal ceiling because no FDA-approved limit exists, but it represents the upper range of what is supported by preclinical scaling and provider experience

Chronic arsenic exposure may also cause epigenetic changes, such as the arsenic-induced depletion of S-adenosylmethionine (SAM), which can alter CpG methylation in gene promoters, including p53 [123,124,125]

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Im tired all the time. My skin looks so dry and dull. My nails keep cracking. Why am I getting sick more often? Youve been to the doctor and your checkup seems clean

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Soares P, Silva C, Chavarria D et al (2023) Drug discovery and amyotrophic lateral sclerosis: emerging challenges and therapeutic opportunities