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Results: Female NOD mice treated with T1D-tolLNPs had significantly reduced diabetes incidence relative to buffer-injected controls (13% vs 67% diabetes-free at 30 weeks, p =0.002)

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6.5 Clinical application and pathological transformation The clinical application of bile-based TCMs requires a deep understanding of Yin-Yang transformation, where the role of specific bile acids may change during different stages of disease progression

Dietary Fiber Is Beneficial for the Prevention of Cardiovascular Disease: An Umbrella Review of Meta-analyses