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And in most cases, the benefits outweigh the costs

This is especially useful for people with B vitamin deficiencies who may feel tired or fatigued throughout the day

Genetics alone does not determine success

G protein-biased agonists represent one promising direction

The big question

Alcohol- and other substance-use disorders may well benefit from the effects of GLP-1RAs on dopamine and opioid pathways that are dysregulated in addiction 243 , as seen in some of the studies we identified, and the same could also apply to other under-investigated disorders with similar underlying dysfunctions (for example, gambling disorder)