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As such, and in response to these comments, we clarify that hospitals should report data from both prior to and after a contract negotiation date to capture a full 12-month period regardless of when the contract negotiation takes place

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The following is a summary of documented tissue systems from peer-reviewed literature: This cross-tissue activity profile is directly attributable to the fact that its primary mechanisms VEGFR2-driven angiogenesis and NO system modulation are not tissue-specific